Professor Paul Harrison's research focuses on the causes of, and the brain abnormalities associated with, schizophrenia. It is known that schizophrenia is largely 'in our genes', and brain development is in some way altered, and that the brain chemicals dopamine and glutamate are involved in the disorder. However, many details are lacking in all these areas, and the ways in which they link together. To address these important questions Harrison's group uses a range of methods and approaches. The ultimate goal is to use the information to improve the treatment and outcome of schizophrenia.